Addendum

what others write

“Dissecting the complex genetic basis of mate choice” is the lengthy title of a lengthy text that tells us

males produce complex signals and displays that can consist of a combination of acoustic, visual, chemical and behavioural phenotypes…

The authors come from a school of integrative biology. I wonder why they have missed the excellent work in humans on HLA, fertility and mate choice.
Having said that, I would even suggest a radical different approach by looking at “What people search for” – hopefully I get now also hits on my blog for Paris Hilton, Renee Zellweger, Britney Spears, Heidi Klum, Pamela Anderson, Jessica Simpson and Jennifer Lopez ;-) Dissecting the complex genetic basis of mate choice shouldn´t be as complicated as you may imagine from this nature reviews genetics paper, yea, yea.

A new paper shows a nice workflow how to do an in vitro prediction which drug will suppress a certain tumor. The authors are simply linking the phenotype of the cell line “50% inhibitory concentration by drug X” with its expression signature. The good news are that doing both in one vial (phenotyping and expression analysis) is leading to excellent results.

Is there any trick to do this also system-wide e.g. for the metabolism of a substance and its signalling pathway? Pharmacogenetics would greatly benefit from such an approach, nay, nay.

Sorry for a misleading title, but it is a nice idea to use heatmaps also for conditional linkage (or SNP association) results. Seen at the Heidelberg meeting. Sorry also, to show a figure that is severely cropped and blurred to maintain the authors right on their data, yea, yea.