I have just found our most recent PLOS paper about asthma in Africa being published online

As of the 1980s, there was an overall conviction that asthma had an anthropogenic origin with indoor and outdoor air pollution as the main culprits. Following some overinterpreted epidemiological findings of the “hygienic” phase, there is now evidence accumulating that the asthma epidemic might have an iatrogenic origin. There might not only be indirect effects of improved living standards and better medical care, there are even direct effects under discussion, for example by oestrogens, vitamin D, antibiotics, and paracetamol. Infant formula (which contains vitamin D) has already entered the food chain in Africa; paracetamol is the most common drug bought over the counter in Ghana. Do African countries offer any unique observations where singular effects of these drugs can be delineated?

An independent review (that I did not know at time of writing) arrived at similar conclusions. We all, however, forgot to mention sensational news as Gambian president Yahya Jammeh can heal asthma click – click – a more serious appraisal click.

My childhood favorites

For documenting a research project I want to insert quick links to previous emails. Clicking a link should kickstart Thunderbird and go directly to a known message. Mozilla.org says

Athough Google desktop is able to do it, there is no clear API to instruct Thunderbird to display a given email stored in its mail box (knowing the folder & message ID)

Here is how Google Desktop Search (GDS) links to an email

What I have found out so far by comparing different links

(1) is the fixed parameter relating to my hard disk??
(2) is a variable parameter relating to the physical location of my \daten\Mail\thunderbird\imap\INBOX file??
(3) is the unique Message-ID that may be seen in Thunderbird with the View Header plugin
(4) the variable salt/seed value that is stored in the registry at HKEY_CURRENT_USER\\Google\\CustomSearch\\Google Desktop Search\\Url which may be retrieved with a 2 line perl script.

So I am ready to construct URLs that link to an email by using GDS. This is, however, not very elegant. Isn’t there any other way (maybe by a Thunderbird extension) to construct and follow links directly to emails? Can somebody trace with Sysinternals Process Explorer what GDS spits out and follow it up at XUL planet ?

Early vitamin D supplementation may have dual effects, protecting against type 1 diabetes and inducing allergy. Is that possible? Yes, individual genes variants may determine the outcome.

In addition to HLA the most prominent type 1 diabetes genes are INS – CTLA4 – PTPN22 – CD25 – IF1H1, the most prominent asthma/allergy genes ADAM33 – DPP10 – IL12 – IL4 – GPR154 – FLG. I can´t see any joint master regulator, however, we know that

• CD25 is the IL2R
• and just learned from an excellent new mouse study that IL2 gene variation impairs regulatory T cell function
• while IL2 variants are associated with allergy
• IL2 is suppressed by vitamin D – known since 1985

Could that be a model to explain the dual involvement of vitamin D in both diseases?

Creativity in science – look how computer are being named (seemed there are many da Vinicis and Picassos in bioinformatics). The MDC microsatellite center in Berlin named their sequencers by volcanos (even before pyrosequencing became in vogue), we use European cities for our freezers. Famous chess players would be another idea or use car brands …