But let your communication be Yea, yea; Nay, nay: for whatsoever is more than these cometh of evil

How to impute marker genotypes

I am currently playing with MACH and SNPMStat to impute marker based on public datasets. I do not have any opinion about the usefulness of this approach – largely due to the fact that ~10% of my allele coding is different to the public hapmap data. (Show me more…)

Saturday, March 8th

Evolutionary psychology and science: The full error list

The appendix of Frey includes a list of errors based on evolutionary psychology (EP) – some acquired during development of our species, some acquired during individual ontogenesis. It is certainly the best what I have read since the famous study biases (Show me more…)

Sunday, March 2nd

How to do better research

There is an interesting new dissertation (“Ulrich Frey. Der blinde Fleck. Kognitive Fehler in der Wissenschaft und ihre evolutionsbiologischen Grundlagen”) that contains a nice game

{democracy:5}

(Show me more…)

Sunday, March 2nd

Is there any environmental conditioning of vitamin D metabolism?

So far, I haven’t seen so much work about epigenetic regulation of vitamin D. There was already a paper in 2005 that showed how treatment with the

methylation inhibitor 5-aza-2′-deoxycytidine together with the deacetylation inhibitor trichostatin A resulted in elevation of both CYP27B1 and CYP24 mRNA expression demonstrating that even in normal human prostate cells expression of Vitamin D hydroxylases may be under epigenetic control

(Show me more…)

Saturday, March 1st
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