As somebody who is dealing most time with large datasets I always arrive at genes and proteins that I do not know. Using Biocarta, Keggs and other services in the past, I find the new WikiPathways exciting and hope that it will grow over the years. A companion paper in PLoS biology describes its roots in GenMAPP and the current work of the authors on bots that identifiy inconsistencies but also pick up loose ends. Hopefully I will find some time to work a bit on nuclear receptors, yea, yea.