Friday, November 17th, 2006
Best of two worlds
Finally, linkage and association data can be used together after downloading new software using genotype inference.
It reduces the number of genotyping reactions and increases the power of genome-wide association studies. Our method combines sparse marker data from a linkage scan and high-resolution SNP genotypes for several individuals to infer genotypes for related individuals.
Sure, we
- could already test association only in linked families
- knew that linkage genome scans will improve the power of association
- could evaluate by stepc if a polymorphisms explains a linkage result
but this seems to be the best recycling for our old fashioned linkage data. Yea, yea.
Related Posts: What could have been learned from linkage studies, Avalanche – backstage story, Once again genetic testing, Bigger is better