Rolf Zinkernagel in a commentary in Nature Immunology explains that today almost everything can be measured – and a nearly uncontrollable complexity often paired with weak detection methods renders experiments almost unrepeatable. His recommendations are

Most if not all experiments have limitations. Therefore researchers must think and argue and do experiments contrary to published results and against biases.

Nearly all studies need some funding; funding is controlled by peer review; peer review usually prohibits these experiments. Yea, yea.