Monday, March 26th, 2007
Another path from vitamin D to allergy
As far as I know vitamin D3 influences only RUNX2 expression (RUNX2 has a VDRE, possibly also RUNX3 but not RUNX1?). The RUNX factors
colocalized in common subnuclear foci. Furthermore, RUNX subnuclear foci contain the co-regulatory protein CBFβ, which heterodimerizes with RUNX factors, and nascent transcripts as shown by BrUTP incorporation. These results suggest that RUNX subnuclear foci may represent sites of transcription containing multi-subunit transcription factor complexes.
Variants in RUNX1 have already been reported earlier to be weakly associated with IgE serum levels in Korea.
A Nature paper todays reports that Foxp3 controls Treg function by interacting with AML1/RUNX1 – is there any connecting path?
Related Posts: Dual vitamin D effects on type 1 diabetes and allergy, Undo button, Lymphopoetin and allergy, Another difference between men and women