Two days ago I heard an interesting by Andreas Beyer about using wiring diagrams as a bioinformatics tool box for simulating complex biological relationships. This is something that can be found also in this recent nat gen review but even more detailed in new work on eQTLs. So far, however, there is not proof that any of these methods behave much better than others in the absence of a gold standard in bioinformatics, yea, yea.