It drives me crazy – the new JACI review with a detailed explanation how VDD (vitamin D deficiency) induces food allergy (FA). Unfortunately, it has never been show that FDD is related to FA – while the opposite may be true… (Show me more…)

I wasn’t sure whether to continue here the 2008 dung hill blog post or just opening a new thread as a colleague just entered my office with the news of (Show me more…)

Here comes the most striking connection between calcium and IgE that updates some earlier posts here

The fact that the regulation of intracellular Ca2+ concentration is different in various T-cell effectors may offer the opportunity to target key intermediates … to inhibit specifically the functions of one given T-cell subset. (Show me more…)

I need to refer here to a post 3 years ago or to the medical literature that genes frequencies changed rapidly between generations.
Although that is even the basis of a submitted Great Challenge Application at the Gates Foundation any empirical proof is scarce so far.
Or I have to say, until this week, when I found a study published earlier in PLoS ONE that tackles this problem: Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population (Show me more…)