Coordinates of truth and hypothesis-generating research

An interesting piece published in Science finds that

The accuracy and predictability of a hypothesis depend on the validity of the inputs used to generate and test it. Because problems are typically complex and information regarding their solution is limited, the solution is more likely to be found if the information base is greater. This rationale is a driving force behind systems biology, which attempts to define biological complexity from a systemic perspective using information technology … High-profile journals publish systems biology studies, including the human genome sequence, but most papers focus on hypothesis-driven investigations.

The most remarkable point here is the fact that there are still more people who believe in an underlying truth. This reminds me to the philosopher Continue reading Coordinates of truth and hypothesis-generating research

ORMDL3 graduated

Given my sceptical view that ORMDL3 is really an asthma gene (that may be even shared by the authors of the initial association) the train has now departed with more groups speculating about ORMDL3 function.
For example this new paper by Gerard Cantero-Recasens is about the unfolded protein response (UPR) that may be triggered by a putative loss of function mutation in ORMDL3 via a Ca2+ decrease in the ER. Although I am quite intrigued about the fact that the story now moves to calcium and vitamin D, we are far away from any conclusive evidence.

Addenddum 3.3.2010

And here is another paper that associates ORMDL3 to the sphingolipid metabolism. Although that may be also an interesting pathway (given a bulk of literature not cited in the paper ( more, more, more, more) I still wonder if this is wishful thinking. The authors do not touch the main problem – the weak connection of some genomic variants in that region to ORMDL3 function to asthma pathogenesis.

SQLite and a graphical ER diagrammer for OS X

I am looking for some time for a MS-Acess like graphical interface addressing my large SQLite databases. Having tried out now more than dozen different packages, I found only one that fills my needs and even that only by 80% – RazorSQL.
Writing complex SQL queries is possible hwith an “autocomplete” function Continue reading SQLite and a graphical ER diagrammer for OS X

Tired of the hygiene hypothesis

A new Thorax review finds

The hypotheses have arisen from a desire to explain epidemiological differences, and those such as the “hygiene” hypothesis had a seemingly corroboratory immunological explanation. However, they have not taken us to the point where we can proudly announce a primary preventive strategy.

I agree with the last statement but have severe doubts on any “immunological explanation” Continue reading Tired of the hygiene hypothesis

The art of a clean Mac OS X desktop

I spent considerable time this week as my MBA showed major quirks – the finder’s trashcan did not respond, clicking on the finder in the dock suddenly opened a second icon, while the finder crashed frequently. Running harddisk maintenance, correcting access rights, deleting several plists, experimenting with safe mode, even deleting PRAM and NVRAM – nothing helped until Continue reading The art of a clean Mac OS X desktop

Tobe, Welt und springe

Bach cantatas are at a nice page of cs.ualberta.ca incuding my favorite BWV 227

Trotz dem alten Drachen,
Trotz des Todes Rachen,
Trotz der Furcht darzu!
Tobe, Welt, und springe,
Ich steh hier und singe
In gar sichrer Ruh.
Gottes Macht hält mich in acht;
Erd und Abgrund muss verstummen,
Ob sie noch so brummen.

How to speed up online banking with a billing “tweed”

It would be nice to have billing details somewhere online while just typing in some Amadeus like 6 digit code to move the data into the online banking page. This not so much a security issue as such a billing tweed should vanish after 4 weeks Continue reading How to speed up online banking with a billing “tweed”

Unscientific World

A review of “Unscientific America” on p 678 in Science Magazine 7 Aug 2009 finds

According to Mooney and Kirshenbaum, atheistic scientists such as Richard Dawkins and P. Z. Myers [who runs the immensely popular science blog Pharyngula] drive people away from science by forcing them to choose between the facts and their faith.

evo-devo-dis

I am curently working on a new lecture series on that topic – having a gut feeling that the evolutionary history will explain how and why we get diseases. Some German magazines (“Fehlkonstruktion Mensch” DER SPIEGEL 40/2009) even write about that topic quoting a forthcoming book of Ganten / Deichmann / Spahl). I will rely, however, mostly on Continue reading evo-devo-dis