The association of IL1RL1 and asthma is usually attributed to our 2009 nature genetics paper, sometime also to the later NEJM paper 2010. We described the association in the IL1 cluster, however, already 6 years earlier in Gohlke et al. 2004. The resolution wasn’t so good at that time as we thought more of IL1RN than IL1RL1. And even in 2004, the IL1 cluster was well known. Why is the temporal order of events so unimportant?