How it is going, how it started – asthma genome wide scans

Here are the most recent GWAS data for asthma – not identical peaks but quite similar

How it is going 2021

 

PMC5901974

big.stats.ox.ac.uk

pheweb.sph.umich.edu

r2.finngen.fi

www.ebi.ac.uk

 

How it started: 1996-1998

third linkage scan (my thesis)

second  linkage scan (CSGA)

first linkage scan (Cookson)

More than 2 decades ago we found hits on chromosome 2, 6, 9, 12 (missing  chr17q21 where our marker coverage wasn’t probably good enough). It seems that this was the first identification of the IL33 region although IL33 could be described only 7 years later. Remarkably,  this result was possible with just 415  individuals instead of 500,000 individuals nowadays (see also the asthma genetics timeline).