How it is going, how it started – asthma genome wide scans

Here are the most recent GWAS data for asthma. Peaks are not identical peaks but quite similar.

How it is going in 2021 …



And here is how it started 1986

third linkage scan (my PhD thesis)

second  linkage scan (CSGA)

first linkage scan (Cookson)


So, more than 2 decades ago we found hits on chromosome 2, 6, 9, 12 (missing  chr17q21 where our marker coverage wasn’t probably good enough). It seems that this was the first identification of the IL33 region although IL33 was described only 7 years later. Remarkably,  this result was possible with just 415  individuals instead of 500,000 individuals nowadays (see also the asthma genetics timeline).