I am sure, I wrote or talked about it before, but cannot find it.
is a quote from a recent Nature column “Beware the creeping cracks of bias”. A great article, that summarizes why the impact oriented biomedical science is at risk producing meaningless and useless results: A biased scientific result is no different from a useless one weiterlesen
I have heard it many times on congresses and there seems now even a meta-analysis of a possible preferential maternal transmission of asthma to children. And of course, there are important biological question behind (imprinting? maternal antibody transfer?) but unfortunately this is nothing else than a spurious effect.
The author’s view is well taken that we did the first modern family study 1992 Clearly biased: Maternal recall of asthma in the family weiterlesen
So far in epidemiology case – control studies are defined by an approach where
… the past histories of patients (the cases) suffering from the condition of interest are compared to the past histories of persons (the controls) who do not have the condition of interest, but who otherwise resemble the cases in such particulars as age and sex ….
I usually explain controls as non-cases in the same overall environment When controls are no controls weiterlesen