Tag Archives: effect sizes

Heritability not limited to DNA sequence differences

It has been our gut feeling for many years – first with candidate gene studies, then with the large scale GWAs that show ridiculous low effect sizes.
A new Canadian study now reports DNA methylation at 12 K sites in dizygotic twins. Although they may not have always tested the right spots (see the CpG island shore! paper in the same issue) they were attributing discordances mainly to zygote differences Continue reading Heritability not limited to DNA sequence differences