Occasionally I see high R^2 values even between linkage disequilibrium blocks. The following plot was obtained from the German asthma family study; basically a haploview screenshot rescaled and inverted before using the Photoshop polar filter. Continue reading Trans-border LD?
It reduces the number of genotyping reactions and increases the power of genome-wide association studies. Our method combines sparse marker data from a linkage scan and high-resolution SNP genotypes for several individuals to infer genotypes for related individuals.
- could already test association only in linked families
- knew that linkage genome scans> will improve the power of association
- could evaluate by stepc if a polymorphisms explains a linkage result
but this seems to be the best recycling for our old fashioned linkage data. Yea, yea.