Tag Archives: phenotypes

The third largest problem in epidemiology

-moblog- In my view, epidemiology is not very flexible to adjust to new methods and new techniques. Following some discussion that I had today with STW about eQTLs (quantitative traits derived by RNA microarrays or metabolome profiles) and JMA about system biology, it is likely that we are facing huge changes. Phenotypes may no more called intermediary and we may soon forget old controversies of disease definition. We will instead use new system-terms like NonImm076Trig31Ste0098 or TLR9-096321-Auto5337. Yea, yea.

Barker to the power of 2

It is certainly hard to understand how early life events are leading to later disease. Here is an incredible nutrigenomics story done in agouti mice:

We find that the somatic epigenetic state of Avy is affected by in utero methyl donor supplementation only when the allele is paternally contributed. Exposure to methyl donor supplementation during midgestation shifts Avy phenotypes not only in the mice exposed as fetuses, but in their offspring. This finding indicates that methyl donors can change the epigenetic state of the Avy allele in the germ line, and that the altered state is retained through the epigenetic resetting that takes place in gametogenesis and embryogenesis. Thus a mother’s diet may have an enduring influence on succeeding generations.