{"id":10384,"date":"2018-07-18T16:25:55","date_gmt":"2018-07-18T15:25:55","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=10384"},"modified":"2018-07-20T07:59:13","modified_gmt":"2018-07-20T06:59:13","slug":"gene-methylation-in-newborns-is-changed-by-maternal-vitamin-d-supplementation","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/07\/gene-methylation-in-newborns-is-changed-by-maternal-vitamin-d-supplementation\/","title":{"rendered":"Gene methylation in newborns is changed by maternal vitamin D supplementation"},"content":{"rendered":"<p><a href=\"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/bfm.2017.0231\">A randomized controlled study<\/a>\u00a0of pregnant women examined 400 IU vitamin D3 vs 3,800 IU from the second trimester through 4-6 weeks postpartum by genome-wide DNA methylation in leukocytes.<\/p>\n<blockquote><p>At birth, intervention group mothers showed DNA methylation gain and loss at 76 and 89 cytosine- guanine (CpG) dinucleotides, respectively, compared to controls. Postpartum, methylation gain was noted at 200 and loss at 102 CpGs. Associated gene clusters showed strongest biologic relevance for cell migration\/ motility and cellular membrane function at birth and cadherin signaling and immune function at postpartum.<\/p><\/blockquote>\n<p>It seems that D3 supplementation is generating epigenetic effects in the offspring, something that we\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22517291\">predicted already in 2012\u00a0<\/a>as programming of vitamin D sensitivity.<\/p>\n<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/07\/screen-4.jpg\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10385 alignnone\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/07\/screen-4.jpg\" alt=\"\" width=\"1297\" height=\"438\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/07\/screen-4.jpg 1297w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/07\/screen-4-620x209.jpg 620w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/07\/screen-4-768x259.jpg 768w\" sizes=\"auto, (max-width: 1297px) 100vw, 1297px\" \/><\/a><\/p>\n<p>When re-annotating the genes above using biocLite(&#8220;mygene&#8221;) there are at least 2 interesting genes for gain of methylation are getting to the surface: ZMIZ1 \u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26522984\">T cell differentiation<\/a>) and CYP7B1 (first reaction in the <a href=\"https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=CYP7B1&amp;keywords=cyp7b1\">cholesterol catabolic pathway<\/a> of extrahepatic tissues, which converts cholesterol to bile acids). But also methylation loss is interesting with HLA-A (antigen processing).<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 20.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A randomized controlled study\u00a0of pregnant women examined 400 IU vitamin D3 vs 3,800 IU from the second trimester through 4-6 weeks postpartum by genome-wide DNA methylation in leukocytes. At birth, intervention group mothers showed DNA methylation gain and loss at 76 and 89 cytosine- guanine (CpG) dinucleotides, respectively, compared to controls. Postpartum, methylation gain was &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/07\/gene-methylation-in-newborns-is-changed-by-maternal-vitamin-d-supplementation\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Gene methylation in newborns is changed by maternal vitamin D supplementation<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[],"class_list":["post-10384","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=10384"}],"version-history":[{"count":9,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10384\/revisions"}],"predecessor-version":[{"id":10396,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10384\/revisions\/10396"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=10384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=10384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=10384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}