{"id":10491,"date":"2018-09-24T11:45:26","date_gmt":"2018-09-24T10:45:26","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=10491"},"modified":"2018-09-24T21:04:31","modified_gmt":"2018-09-24T20:04:31","slug":"what-could-be-done-single-cell-birth-dating","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/09\/what-could-be-done-single-cell-birth-dating\/","title":{"rendered":"What could be done &#8211; single cell birth dating"},"content":{"rendered":"<p>The famous <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867405004083\">Spalding paper<\/a>\u00a02005 used an interesting approach<\/p>\n<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/09\/screen.jpg\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10494 alignnone\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2018\/09\/screen.jpg\" alt=\"\" width=\"497\" height=\"402\" \/><\/a><\/p>\n<blockquote><p>We show that the level of 14C in genomic DNA closely parallels atmospheric levels and can be used to establish the time point when the DNA was synthesized and cells were born&#8230; Retrospective birth dating is a generally applicable strategy that can be used to measure cell turn-over in man under physiological and pathological conditions.<\/p><\/blockquote>\n<p>I was more in <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/01\/a-longe-fuse\/\">favor of calculating mutation rates<\/a>, S. Horvath <a href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/gb-2012-13-10-r97\">suggested methylation changes<\/a>. Maybe\u00a0<a href=\"https:\/\/www.cell.com\/abstract\/S0092-8674%2812%2900003-7\">lineage tracking<\/a> will be the next big thing in <a href=\"https:\/\/en.wikipedia.org\/wiki\/Single-cell_analysis\">single cell analysis<\/a> and the <a href=\"https:\/\/www.humancellatlas.org\">human cell atlas?<\/a><\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 01.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>The famous Spalding paper\u00a02005 used an interesting approach We show that the level of 14C in genomic DNA closely parallels atmospheric levels and can be used to establish the time point when the DNA was synthesized and cells were born&#8230; Retrospective birth dating is a generally applicable strategy that can be used to measure cell &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/09\/what-could-be-done-single-cell-birth-dating\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">What could be done &#8211; single cell birth dating<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-10491","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=10491"}],"version-history":[{"count":4,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10491\/revisions"}],"predecessor-version":[{"id":10497,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/10491\/revisions\/10497"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=10491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=10491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=10491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}