{"id":11340,"date":"2018-12-28T07:17:54","date_gmt":"2018-12-28T06:17:54","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=11340"},"modified":"2018-12-28T07:28:15","modified_gmt":"2018-12-28T06:28:15","slug":"paternal-mitochondrial-inheritance","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/12\/paternal-mitochondrial-inheritance\/","title":{"rendered":"Paternal mitochondrial inheritance"},"content":{"rendered":"

So far I thought this is not happening in humans, but a \u00a0PNAS<\/a> paper published this month shows it may be even a genetic trait as\u00a0the authors found biparental mtDNA inheritance in 17 members in three multi-generation families.
\nThere are around 50-75 mitochondria in a single sperm<\/a> which appears\u00a0to be a quite low number (\u223c0.1%) relative to the number maternal mitochondria.
\nThis unexpected paternal origin of mtDNA raises questions how exactly paternal mtDNA can escape its normal fate of being eliminated from the embryo. Are paternal mitos just being diluted and there is much more (micro-)heteroplasmy than currently known?
\nI don’t know why the authors didn’t do formal linkage analysis. And I also don’t know if their conclusion is correct “that occasional paternal transmission events seem to have left no detectable mark on the human genetic record”\u00a0not citing an 1996 PNAS paper<\/a><\/p>\n

In the majority of mammals\u2014including humans\u2014the midpiece mitochondria can be identified in the embryo even though their ultimate fate is unknown. The \u201cmissing mitochondria\u201d story seems to have survived\u2014and proliferated\u2014unchallenged in a time of contention between hypotheses of human origins, because it supports the \u201cAfrican Eve\u201d model of recent radiation of Homo sapiens<\/em> out of Africa.<\/p><\/blockquote>\n

In the age of single cell sequencing it may no more be adequate to believe in maternal inheritance alone.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 05.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

So far I thought this is not happening in humans, but a \u00a0PNAS paper published this month shows it may be even a genetic trait as\u00a0the authors found biparental mtDNA inheritance in 17 members in three multi-generation families. There are around 50-75 mitochondria in a single sperm which appears\u00a0to be a quite low number (\u223c0.1%) … Continue reading Paternal mitochondrial inheritance<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3085,3086,2512,3087],"class_list":["post-11340","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-dawkin","tag-watchmaker","tag-evolution","tag-wrong"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=11340"}],"version-history":[{"count":3,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11340\/revisions"}],"predecessor-version":[{"id":11347,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11340\/revisions\/11347"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=11340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=11340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=11340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}