{"id":11352,"date":"2019-01-19T08:24:03","date_gmt":"2019-01-19T07:24:03","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=11352"},"modified":"2025-02-04T19:34:25","modified_gmt":"2025-02-04T17:34:25","slug":"ivf-eine-zeitbombe","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/01\/ivf-eine-zeitbombe\/","title":{"rendered":"IVF eine Zeitbombe?"},"content":{"rendered":"

Nachdem es also doch so viele IVFs<\/a>\u00a0in Deutschland gibt (12.000 IVF bei 785.000 Geburten im Jahr ), w\u00e4re es doch mal interessant, was es an Sp\u00e4twirkungen f\u00fcr die IVF Kinder gibt, sobald sie das niedrige Geburtsgewicht und\u00a0angeborene Defekte<\/a>\u00a0\u00fcberlebt haben.<\/p>\n

\"\"<\/a>
S. 22 Jahrbuch Deutsches IVF Register 2018<\/figcaption><\/figure>\n

Aus zwei Gr\u00fcnden ist die Frage allerdings nicht ganz leicht zu beantworten. Erstens gibt es bisher keine IVF Kinder, die \u00e4lter als 40 Jahre sind<\/a> und damit gibt es auch keine Erfahrung mit den typischen Krankheiten ab 60 Jahre.<\/p>\n

Und zweitens gibt es diverse Krankheiten der Eltern, die \u00fcberhaupt erst zur IVF gef\u00fchrt haben, aber nicht der IVF selbst angelastet werden k\u00f6nnen. Zudem sind IVF M\u00fctter deutlich \u00e4lter als im Durchschnitt, was\u00a0selbst schon ein Krankheitsrisiko f\u00fcr die Kinder bedeutet.<\/p>\n

Zumindestens in der Theorie, ist die IVF nicht ganz ungef\u00e4hrlich f\u00fcr den Embryo – man braucht Hormone und ein k\u00fcnstliches<\/a>\u00a0Medium<\/a>, was vor allem\u00a0 den Methylierungsstatus<\/a> der Embryos beeinflusst (dazu gibt es mehrere Studien<\/a>, die wichtigste von\u00a02015<\/a>). Eigenartigerweise gibt es aber nur wenig klinische Literatur zu dem Thema und Null Information am Deutschen IVF Register. Das Register schreibt mir am 31.12., da\u00df Auswertungen zu Sp\u00e4tfolgen nicht zu den Standardauswertungen des Deutschen IVF-Registers geh\u00f6ren. Macht das Register also prim\u00e4r PR?<\/p>\n

Die fehlenden Studienbasis fiel auch vor kurzem dem Independent<\/a> auf.\u00a0 Das \u00a0 letzte medizinische \u00a0IVF Review<\/a>\u00a0 ist leider schon etwas angejahrt. Beschriebene Risiken sind vor allem Depression im fr\u00fchen Erwachsenenalter, Alkoholismus, erh\u00f6hter\u00a0Bluthochdruck<\/a>, erh\u00f6hter N\u00fcchternzucker, erh\u00f6hter BMI, vorzeitige Knochenalterung sowie Schilddr\u00fcsenerkrankungen. \u00a0Hypertonie h\u00f6rt sich harmlos an, \u00a0wird \u00a0aber als ein Symptom einer vorzeitigen Gef\u00e4\u00dfalterung<\/a>\u00a0gewertet.<\/div>\n

Eigentlich m\u00fcsste es regelm\u00e4ssige Kontrolluntersuchungen nach IVF geben, am besten im Rahmen klinischer Studien. \u00a0Nicht umsonst wird auch die Richtlinie der assistierte Reproduktion gerade komplett neu verfasst, da die alte unbrauchbar war.<\/p>\n

<\/p>\n

Translation<\/p>\n

Since there are so many IVF treatments in Germany (12,000 IVF treatments for 785,000 births per year), it would be interesting to know what late effects there are for IVF children once they have survived low birth weight and congenital defects.However, answering this question is not entirely easy for two reasons.<\/p>\n

First, there are no IVF children older than 40 years, so there is no experience with typical diseases that occur after the age of 60.
\nAnd second, there are various parental diseases that led to IVF in the first place, but cannot be attributed to the IVF procedure itself. Furthermore, IVF mothers are significantly older than average, which in itself poses a health risk to the children.<\/p>\n

At least in theory, IVF is not entirely risk-free for the embryo, as hormones and an artificial medium are required, which mainly affect the methylation status of the embryos (there are several studies on this, the most important one from 2015). Strangely enough, there is very little clinical literature on this topic, and no information is available from the German IVF Register. The Register wrote to me on December 31 that evaluations of late effects are not yet part of the standard evaluations of the German IVF Register (D\u00b7I\u00b7R). Is the Register with its fancy pictures is primarily used for PR purposes?<\/p>\n

The lack of a study base was also recently noted by Independent. The last medical IVF review is unfortunately somewhat outdated. The risks described are primarily depression in early adulthood, alcoholism, high blood pressure, elevated fasting glucose, increased BMI, premature bone aging, and thyroid diseases. Hypertension sounds harmless but is considered a symptom of premature vascular aging. In fact, regular follow-up examinations after IVF should be conducted, preferably as part of clinical studies. Not without reason, the guidelines for assisted reproduction are currently being completely rewritten because the old ones were obsolete.<\/p>\n

 <\/p>\n

Postscriptum 4\/2\/2025<\/span><\/p>\n

FAZ<\/a> has an overview article that includes risk like\u00a0 Beckwith-Wiedemann syndrome and heart birth defects\u00a0 along with cleft lip\/palate, and misplaced urethra. While 4.6% of naturally conceived children have such defects, the rate for IVF children is 6.1% according to a 2024 study.<\/a><\/p>\n

To eliminate such uncertainties, German researchers have been following hundreds of ICSI offspring in a unique long-term study since birth, comparing them with children conceived naturally. The project began at the University of L\u00fcbeck. The 274 participants in the most recent publication from 2020 were already an average of 16 years old. … The girls developed normally during puberty but had slightly higher blood lipid levels. In the boys, hormone levels were slightly altered, and they weighed more. In some cases, there were indications of testicular dysfunction, the researchers wrote. This could be due to the fact that ICSI allows men with defective sperm to father children. Their potentially damaged Y chromosome is passed on to their sons. However, whether this means the boys will also be infertile cannot yet be determined.<\/p><\/blockquote>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/32240284\/<\/a>
\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10328861<\/a><\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 07.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Nachdem es also doch so viele IVFs\u00a0in Deutschland gibt (12.000 IVF bei 785.000 Geburten im Jahr ), w\u00e4re es doch mal interessant, was es an Sp\u00e4twirkungen f\u00fcr die IVF Kinder gibt, sobald sie das niedrige Geburtsgewicht und\u00a0angeborene Defekte\u00a0\u00fcberlebt haben. Aus zwei Gr\u00fcnden ist die Frage allerdings nicht ganz leicht zu beantworten. Erstens gibt es bisher … Continue reading IVF eine Zeitbombe?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-11352","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=11352"}],"version-history":[{"count":16,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11352\/revisions"}],"predecessor-version":[{"id":24617,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/11352\/revisions\/24617"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=11352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=11352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=11352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}