{"id":12414,"date":"2019-04-21T11:13:57","date_gmt":"2019-04-21T10:13:57","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=12414"},"modified":"2019-04-21T23:28:42","modified_gmt":"2019-04-21T22:28:42","slug":"forget-about-plasma-vitamin-d-measurements","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/04\/forget-about-plasma-vitamin-d-measurements\/","title":{"rendered":"Forget about plasma vitamin D measurements"},"content":{"rendered":"<p>I have written in <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30972779\">my recent editorial<\/a> about the nonsense of plasma vitamin D measurements. A recent <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1807841\">case history<\/a> of a patient with a deleted vitamin D carrier molecule GC now confirms the free-hormone hypothesis.\u00a0The patient\u2019s plasma 25(OH)D levels was only 0.4% of those in the unaffected sibling.<\/p>\n<blockquote><p>Despite a lifelong deficiency of vitamin D binding protein, limited sun exposure (for religious reasons), and a diet that was probably lacking sufficient vitamin D, our patient did not have rickets or osteomalacia but rather osteopenia and fragility fractures that occurred in the fifth decade of life.<\/p><\/blockquote>\n<p>Another carrier sibling had only two third of the plasma 25(OH)D level compared to the unaffected sibling but showed &#8220;no appreciable clinical manifestations&#8221;.<br \/>\nSo why measure 25(OH)D?<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I have written in my recent editorial about the nonsense of plasma vitamin D measurements. A recent case history of a patient with a deleted vitamin D carrier molecule GC now confirms the free-hormone hypothesis.\u00a0The patient\u2019s plasma 25(OH)D levels was only 0.4% of those in the unaffected sibling. Despite a lifelong deficiency of vitamin D &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/04\/forget-about-plasma-vitamin-d-measurements\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Forget about plasma vitamin D measurements<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[],"class_list":["post-12414","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=12414"}],"version-history":[{"count":7,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12414\/revisions"}],"predecessor-version":[{"id":12421,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12414\/revisions\/12421"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=12414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=12414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=12414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}