{"id":1253,"date":"2007-10-08T19:24:29","date_gmt":"2007-10-08T17:24:29","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/10\/08\/pax5-and-allergy\/"},"modified":"2007-10-12T14:38:55","modified_gmt":"2007-10-12T12:38:55","slug":"pax5-and-allergy","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/10\/pax5-and-allergy\/","title":{"rendered":"Pax5 and allergy"},"content":{"rendered":"<p>Transcription factor Pax5 is a key regulator for the B cell lineage (it may even be reponsible for redifferentiation from B to T cells according to new research from the <a href=\"http:\/\/www.nature.com\/nature\/journal\/v449\/n7161\/abs\/nature06159.html\">Busslinger lab<\/a>). As human CD23a, the low affinity IgE receptor, <a href=\"http:\/\/www3.interscience.wiley.com\/cgi-bin\/abstract\/104519935\/ABSTRACT\">has a functional Pax-5-binding site<\/a>, there could be a relationship to allergy inheritance. So far I have only looked into Pax-8 while Pax-5 might be even more important.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 10.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Transcription factor Pax5 is a key regulator for the B cell lineage (it may even be reponsible for redifferentiation from B to T cells according to new research from the Busslinger lab). As human CD23a, the low affinity IgE receptor, has a functional Pax-5-binding site, there could be a relationship to allergy inheritance. So far &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/10\/pax5-and-allergy\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Pax5 and allergy<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[1292,1290,307,1291,1289],"class_list":["post-1253","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","tag-binding_site","tag-cell_lineage","tag-ige","tag-pax","tag-transcription_factor"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1253","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1253"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1253\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1253"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1253"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}