{"id":1285,"date":"2007-10-20T10:02:58","date_gmt":"2007-10-20T10:02:58","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/10\/20\/auto-desensitization\/"},"modified":"2019-07-08T13:10:10","modified_gmt":"2019-07-08T13:10:10","slug":"auto-desensitization","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/10\/auto-desensitization\/","title":{"rendered":"Auto desensitization"},"content":{"rendered":"<p><a href=\"https:\/\/www.wjst.de\/blog\/2007\/09\/21\/time-to-give-blackley-the-credit-he-deserves\/\">Blackley<\/a> found already in 1873 an interesting explanation of the &#8220;no allergy in farming children&#8221; effect by referring to some kind of auto desensitization in this particular environment &#8211; e.g. the high pollen and LPS exposure.<br \/>\nDo you know that a commercial allergen preparation used for desensitization already includes a LPS derivate, 3-o-desacyl-4&#8242; monophosphoryl lipid A as an adjuvant? It is believed to push the pollen reaction into a IL12 &#8211; IFNg &#8211; Th1 pathway. This therapeutic approach already perfectly fits the early explanation of Blackley.<br \/>\nWhen will the allergy farming lobby ultimately close their files?<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 14.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Blackley found already in 1873 an interesting explanation of the &#8220;no allergy in farming children&#8221; effect by referring to some kind of auto desensitization in this particular environment &#8211; e.g. the high pollen and LPS exposure. Do you know that a commercial allergen preparation used for desensitization already includes a LPS derivate, 3-o-desacyl-4&#8242; monophosphoryl lipid &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/10\/auto-desensitization\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Auto desensitization<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[1327,199,1324,1096,1326,412,1325],"class_list":["post-1285","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","tag-adjuvant","tag-allergy","tag-desensitization","tag-farming","tag-lps","tag-pathway","tag-pollen"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1285"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1285\/revisions"}],"predecessor-version":[{"id":12960,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1285\/revisions\/12960"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}