{"id":12920,"date":"2019-10-16T05:32:03","date_gmt":"2019-10-16T05:32:03","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=12920"},"modified":"2020-10-31T15:56:31","modified_gmt":"2020-10-31T15:56:31","slug":"allergy-protection-on-farms-why-also-studies-in-mice-could-have-failed","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/10\/allergy-protection-on-farms-why-also-studies-in-mice-could-have-failed\/","title":{"rendered":"Allergy protection on farms &#8211; why also studies in mice could have failed"},"content":{"rendered":"<p>There are\u00a0 many immunological differences in humans and mice (<a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/12\/on-mice-and-men-with-asthma\/\">follow my link<\/a>) that are never discussed &#8212; not even in <a href=\"https:\/\/science.sciencemag.org\/content\/349\/6252\/1106\/tab-pdf\">Science 2015;349\/6252:1106<\/a>.<\/p>\n<p>Ignoring <a href=\"https:\/\/www.jacionline.org\/article\/S0091-6749(02)08568-8\/fulltext\">the long-standing paradox<\/a> that endotoxin is also acting as a natural adjuvant to atopic inflammation, the credibility of the Science paper is further reduced.<\/p>\n<p>IMHO it is also a\u00a0 strange experimental condition to have all animals on a standard vitamin D diet &#8211; a known co-sensitizers &#8211; and looking then for <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15862966\">A20 which is co-regulated by vitamin D<\/a> ??<\/p>\n<p>And here is the last argument &#8211; more than 90% of studies in mice <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25541546\/\">fail to translate into humans<\/a>.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 09.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>There are\u00a0 many immunological differences in humans and mice (follow my link) that are never discussed &#8212; not even in Science 2015;349\/6252:1106. Ignoring the long-standing paradox that endotoxin is also acting as a natural adjuvant to atopic inflammation, the credibility of the Science paper is further reduced. IMHO it is also a\u00a0 strange experimental condition &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/10\/allergy-protection-on-farms-why-also-studies-in-mice-could-have-failed\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Allergy protection on farms &#8211; why also studies in mice could have failed<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[3557,2816,1096,654,742,3163],"class_list":["post-12920","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-animal-studies","tag-fail","tag-farming","tag-helminth","tag-mice","tag-von-mutius"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=12920"}],"version-history":[{"count":8,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12920\/revisions"}],"predecessor-version":[{"id":17399,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/12920\/revisions\/17399"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=12920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=12920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=12920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}