{"id":13,"date":"2006-08-07T16:27:34","date_gmt":"2006-08-07T14:27:34","guid":{"rendered":"http:\/\/146.107.134.84\/wordpress\/index.php\/2006\/08\/07\/how-deep-is-deep-enough\/"},"modified":"2006-08-08T18:01:26","modified_gmt":"2006-08-08T16:01:26","slug":"how-deep-is-deep-enough","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/08\/how-deep-is-deep-enough\/","title":{"rendered":"How deep is deep enough?"},"content":{"rendered":"<p>In case that the common disease \/ common variant is leading to <em>nirvana<\/em>, we urgently need to resequence common genes in large populations. 2kb long CRP is a particular good candidate which might be a reason why <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&#038;cmd=Retrieve&#038;dopt=AbstractPlus&#038;list_uids=16550411&#038;query_hl=39&#038;itool=pubmed_docsum\">Crawford from Uwash<\/a> resequenced ~500 individuals. They found indeed potentially relevant codings SNPs &#8211; of course rare (&lt;1%) but they are  there! There is a greater number in African-Americans than other populations and more than half are private to a single population (BTW more than half in dbSNP can not be validated). Of course tag SNPs would not discover them. Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 28.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>In case that the common disease \/ common variant is leading to nirvana, we urgently need to resequence common genes in large populations. 2kb long CRP is a particular good candidate which might be a reason why Crawford from Uwash resequenced ~500 individuals. They found indeed potentially relevant codings SNPs &#8211; of course rare (&lt;1%) &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/08\/how-deep-is-deep-enough\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">How deep is deep enough?<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945],"class_list":["post-13","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=13"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=13"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}