{"id":1335,"date":"2007-11-19T20:42:46","date_gmt":"2007-11-19T18:42:46","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/11\/19\/finally-the-s2-receptor\/"},"modified":"2018-01-24T11:21:33","modified_gmt":"2018-01-24T10:21:33","slug":"finally-the-s2-receptor","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/11\/finally-the-s2-receptor\/","title":{"rendered":"Finally the \u00df2 receptor"},"content":{"rendered":"<p>The full crystal structure of the \u00df2 receptor is now clear after many attempts for its low natural abundance &#8211; with the extracellular domain still difficult to resolve (more on the relevance of the mutations depicted in Fig.1 in my recent <a href=\"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140-6736(06)69262-3\">Lancet editorial<\/a>). Interesting: the effects of mutations on distant sites by breaking off van der Waals interactions like I135 that disrupt a ionic lock simply by a more loosely packed molecule.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 08.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>The full crystal structure of the \u00df2 receptor is now clear after many attempts for its low natural abundance &#8211; with the extracellular domain still difficult to resolve (more on the relevance of the mutations depicted in Fig.1 in my recent Lancet editorial). Interesting: the effects of mutations on distant sites by breaking off van &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/11\/finally-the-s2-receptor\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Finally the \u00df2 receptor<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-1335","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1335"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1335\/revisions"}],"predecessor-version":[{"id":9396,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1335\/revisions\/9396"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}