{"id":1336,"date":"2007-11-20T20:25:26","date_gmt":"2007-11-20T18:25:26","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/11\/20\/monorail\/"},"modified":"2007-11-20T22:09:07","modified_gmt":"2007-11-20T20:09:07","slug":"monorail","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/11\/monorail\/","title":{"rendered":"Monorail"},"content":{"rendered":"<p>X chromosomal inactivation is difficult enough to understand &#8211; there are now some more data on autosomal monoallelic expression (<a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/full\/318\/5853\/1077\">editorial<\/a> &#038; <a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/abstract\/sci;318\/5853\/1136\">paper<\/a>). Up to 10% of 4,000 genes in clonal cell lines were found to be monoallelic expressed (and up to 20% in some B cell clones). Only odorant and T cell receptors are selectively expressed while all other genes are thought to be randomly silenced.<br \/>\nI wonder how any transmission disequilibrium test makes sense if a variant is only transmitted to a silent chromosome? Possibly there are also epigenetic feedback loops where proteins can remodel chromatin and induce epigenetic marks ultimately silencing a chromosomal region. In any case, a fundamental paper, yea, yea! <\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 07.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>X chromosomal inactivation is difficult enough to understand &#8211; there are now some more data on autosomal monoallelic expression (editorial &#038; paper). Up to 10% of 4,000 genes in clonal cell lines were found to be monoallelic expressed (and up to 20% in some B cell clones). Only odorant and T cell receptors are selectively &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/11\/monorail\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Monorail<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1336","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1336"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}