{"id":1338,"date":"2007-11-19T20:00:31","date_gmt":"2007-11-19T18:00:31","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/11\/19\/first-25oh-d3-gwa-online\/"},"modified":"2022-04-20T06:04:32","modified_gmt":"2022-04-20T04:04:32","slug":"first-25oh-d3-gwa-online","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/11\/first-25oh-d3-gwa-online\/","title":{"rendered":"First 25OH-D3 GWA online"},"content":{"rendered":"

The first genomewide association for vitamin D serum levels is already online as the Framingham people told me earlier this day, many thanks<\/a>!<\/p>\n

\"d3gwa.png\"<\/a><\/p>\n

There are 3 important regions on the above figure figure: around rs1394615, rs1877165 and rs2160595, see also the attached excel sheet fram25ohdexam6or7agesexadj.xls<\/a>.<\/p>\n

What are the reasons that my linkage study<\/a> arrived at completely different regions? The accompanying BMC Genetics paper<\/a> even highlights 2 different SNPs: rs1048516 + rs10507577). Anyway, the best region in my opinion is on chromosome 6. Here are the significant SNPs in relation to their neighboring genes:<\/p>\n

\"fram25ohdexam6or7agesexadj.png\"<\/a><\/p>\n

The phosphodiesterase PDE10A on the right is leading to PUBMED entries on schizophrenia<\/a> and diabetes<\/a>. Asthma is also not so far away with phosphodiesterase inhibitors like theophylline. Isn’t that nice? Quaking (QKI) on the left is also a schizophrenia gene<\/a>, and defective smooth muscle<\/a> in QKI k.o. may relate to asthma as well.<\/p>\n

Does LD explain joint SNP effects?
\n\"ldinpde10a.png\"<\/a><\/p>\n

maybe, maybe not… Is it a known candidate region?<\/p>\n

\"c6candid.png\"<\/a><\/p>\n

Not so far<\/a>.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 10.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

The first genomewide association for vitamin D serum levels is already online as the Framingham people told me earlier this day, many thanks! There are 3 important regions on the above figure figure: around rs1394615, rs1877165 and rs2160595, see also the attached excel sheet fram25ohdexam6or7agesexadj.xls. What are the reasons that my linkage study arrived at … Continue reading First 25OH-D3 GWA online<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,10],"tags":[1387,1114,1388,578],"class_list":["post-1338","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-sunshine-vitamin","tag-framingham","tag-gwa","tag-serum_level","tag-vitamin_d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1338"}],"version-history":[{"count":2,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1338\/revisions"}],"predecessor-version":[{"id":19845,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1338\/revisions\/19845"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}