{"id":13398,"date":"2019-09-16T10:49:44","date_gmt":"2019-09-16T10:49:44","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=13398"},"modified":"2024-12-09T14:29:40","modified_gmt":"2024-12-09T12:29:40","slug":"vitamin-d-polygenic-risk-score-is-not-associated-with-any-disease","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/09\/vitamin-d-polygenic-risk-score-is-not-associated-with-any-disease\/","title":{"rendered":"Vitamin D polygenic risk score is not associated with any disease"},"content":{"rendered":"<p>It is one of the minor papers in a minor journal but nevertheless has some big impact: &#8220;A phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank&#8221;\u00a0 in<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31518429\"> Int J Epidemiol. 2019 Sep 13<\/a><\/p>\n<blockquote><p>Existing studies suggest that a low vitamin D level is associated with more than 130 outcomes. &#8230;\u00a0We then implemented a Mendelian Randomization-Phenome Wide Association Study (MR-PheWAS) analysis on data from 339\u00a0256 individuals of White British origin from UK Biobank. We first ran a PheWAS analysis to test the associations between a 25(OH)D polygenic risk score and 920 disease outcomes&#8230;The PheWAS analysis did not identify any health outcome associated with the 25(OH)D polygenic risk score.<\/p><\/blockquote>\n<p>The message is clear &#8211; <a href=\"https:\/\/www.bmj.com\/content\/348\/bmj.g2035\">we know it for years<\/a>.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 17.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>It is one of the minor papers in a minor journal but nevertheless has some big impact: &#8220;A phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank&#8221;\u00a0 in Int J Epidemiol. 2019 Sep 13 Existing studies suggest that a low vitamin D level is associated with more than &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/09\/vitamin-d-polygenic-risk-score-is-not-associated-with-any-disease\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Vitamin D polygenic risk score is not associated with any disease<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[2940],"class_list":["post-13398","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-vitamin-d-deficiency"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=13398"}],"version-history":[{"count":3,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13398\/revisions"}],"predecessor-version":[{"id":24374,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13398\/revisions\/24374"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=13398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=13398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=13398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}