{"id":13506,"date":"2019-09-27T06:25:07","date_gmt":"2019-09-27T06:25:07","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=13506"},"modified":"2019-10-16T06:44:52","modified_gmt":"2019-10-16T06:44:52","slug":"claim-to-fame-of-the-hygiene-hypothesis","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2019\/09\/claim-to-fame-of-the-hygiene-hypothesis\/","title":{"rendered":"Claim to fame of the hygiene hypothesis"},"content":{"rendered":"

The recent encyclopedia article<\/a> about the hygiene hypothesis seems to be well written. At least on the first instance … in reality it is more a novel than a scientific review.<\/p>\n

For many years already, the hygiene hypothesis has been called an outdated concept; various times it was revised and transformed, and finally it gave birth to novel hypotheses.<\/p><\/blockquote>\n

In other words, the hypothesis has been rejected for being wrong . Even many revisions did not change that. There seem to be only one proven fact – the obsession of some authors with hygiene and nouvel Rousseauism.<\/p>\n

Anyway, the hygiene hypothesis has promoted radical rethinking of infections, microbiota, and coevolution of mankind and microbes.<\/p><\/blockquote>\n

There is nothing radical in backward thinking. We still carry tons of microbes, freezer and antibiotics only did some qualitative but not so much quantitative changes,<\/p>\n

With the advent of novel high-throughput sequencing technologies the human microbiome, which is sometimes called the \u2018forgotten organ,\u2019 has attracted much attention and is currently being implemented in a wider concept of self-foreign relationship, which may even include recognition of the nonmicrobial nonself as a vital stimulus to a well-developing immune system.<\/p><\/blockquote>\n

    \n
  1. So the interest is technology and not science driven.<\/li>\n
  2. The microbiome is not an organ.<\/li>\n
  3. The hype is already over.<\/li>\n
  4. The Self is not defined by any bacterium.<\/li>\n
  5. Most bacteria are excreted and not vital stimulus.<\/li>\n<\/ol>\n

    Given the many molecule classes regulating immune functions across individuals such as short RNAs, the hygiene hypothesis may eventually come back as a surprising explanation of the phenomena evoked by crowding, day care, sibship size, orofecally transmitted diseases, and respiratory infections.<\/p><\/blockquote>\n

    Why that?
    \nA comeback of the hygiene hypothesis by short RNA?
    \nThe listed phenomena are not intrinsically related, but are occuring only at the same time scale.<\/p>\n

    Even the old birth order effect might be rediscovered as epigenetic programming someday. Admittedly, these notions are entirely hypothetical, but without hypotheses, proven or not, science hardly advances.<\/p><\/blockquote>\n

    So if David Strachan’s birth order effect would be really caused by\u00a0 epigenetic programming – why would that be related to hygiene at all?<\/p>\n

    Science is is not so much about proven or unproven but about reasonable and non reasonable hypotheses.<\/p>\n

    \"\"<\/a> \u00a0\"\"<\/a> \"\"<\/a> \"\"<\/a>
    \n    \"\"<\/a><\/p><\/blockquote>\n\n

     <\/p>\n

    \n CC-BY-NC Science Surf , accessed 01.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

    The recent encyclopedia article about the hygiene hypothesis seems to be well written. At least on the first instance … in reality it is more a novel than a scientific review. For many years already, the hygiene hypothesis has been called an outdated concept; various times it was revised and transformed, and finally it gave … Continue reading Claim to fame of the hygiene hypothesis<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[3229,1096,717,298,3163],"class_list":["post-13506","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","tag-ege","tag-farming","tag-hygiene","tag-hypothesis","tag-von-mutius"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=13506"}],"version-history":[{"count":5,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13506\/revisions"}],"predecessor-version":[{"id":13524,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/13506\/revisions\/13524"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=13506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=13506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=13506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}