{"id":1374,"date":"2007-12-04T09:29:51","date_gmt":"2007-12-04T07:29:51","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/12\/04\/best-allergy-paper-2007\/"},"modified":"2007-12-04T09:29:51","modified_gmt":"2007-12-04T07:29:51","slug":"best-allergy-paper-2007","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/12\/best-allergy-paper-2007\/","title":{"rendered":"Best allergy paper 2007"},"content":{"rendered":"<p>The end of the year 2007 is approaching very fast. I can already vote for the best allergy paper in 2007 &#8211; it is a paper from Vienna by <a href=\"http:\/\/download.journals.elsevierhealth.com\/pdfs\/journals\/0091-6749\/PIIS0091674907019483.pdf\">Victoria Leb<\/a> about the molecular and functional analysis of the Ambrosia antigen T cell receptor. They have been able to isolate and transfer alpha (TRAV17-TRAJ45) and beta chain (TRBV18,TRBD1 and TRBJ2-7) TCR chains into Jurkat cells and even other human blood lymphocytes with convicing evidence that the infected cells were Ambrosia Art V1 reactive.<br \/>\nThis opens brand new perspectives for developing a truely allergic TCR transgenic mouse that can be easily challenged and desensitized. It may even allow immediate testing of a variety of substance (and constructs) to ultimately cure allergy. My favorite is to feed DCs with antigen coupled to a T cell <a href=\"http:\/\/www.translational-medicine.com\/content\/4\/1\/26\/figure\/F5?highres=y\">suicide program<\/a> on succesfull <a href=\"http:\/\/respiratory-research.com\/content\/3\/1\/7\/figure\/F1?highres=y\">antigen presentation<\/a>.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>The end of the year 2007 is approaching very fast. I can already vote for the best allergy paper in 2007 &#8211; it is a paper from Vienna by Victoria Leb about the molecular and functional analysis of the Ambrosia antigen T cell receptor. They have been able to isolate and transfer alpha (TRAV17-TRAJ45) and &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/12\/best-allergy-paper-2007\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Best allergy paper 2007<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[199,1401,1400,1405,1404,1406,1403,1402],"class_list":["post-1374","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-allergy","tag-ambrosia","tag-antigen_presentation","tag-beta_chain","tag-cell_suicide","tag-desensitized","tag-tcr","tag-transgenic_mouse"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1374"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1374\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}