{"id":1394,"date":"2007-12-13T23:42:01","date_gmt":"2007-12-13T21:42:01","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/12\/13\/annotation-of-regulatory-sequences-is-largely-insufficient\/"},"modified":"2007-12-17T18:19:47","modified_gmt":"2007-12-17T16:19:47","slug":"annotation-of-regulatory-sequences-is-largely-insufficient","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/12\/annotation-of-regulatory-sequences-is-largely-insufficient\/","title":{"rendered":"Annotation of regulatory sequences is largely insufficient"},"content":{"rendered":"<p>Of a proven set of <a href=\"http:\/\/www.genome.org\/cgi\/reprint\/gr.6929408v1\">regulatory regions<\/a> in zebrafish, computer programs find only between 29% and 61% of the true motifs. This does not come very much unexpected given the vast array of data shown by the Encode project. It even relates to the most basic question: <a href=\"http:\/\/www.nature.com\/nature\/journal\/v441\/n7092\/full\/441398a.html\">What is a gene<\/a>?<\/p>\n<blockquote><p>\nThe more expert scientists become in molecular genetics, the less easy it is to be sure about what, if anything, a gene actually is.\n<\/p><\/blockquote>\n<p>iwith at least 5772 <a href=\"http:\/\/www.wi.mit.edu\/research\/faculty\/bartel.html\">21U-RNAs<\/a>? So &#8211;  if I am sitting on the other side of the table when you are being examined don&#8217;t talk about junk DNA anymore, yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 11.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Of a proven set of regulatory regions in zebrafish, computer programs find only between 29% and 61% of the true motifs. This does not come very much unexpected given the vast array of data shown by the Encode project. It even relates to the most basic question: What is a gene? The more expert scientists &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/12\/annotation-of-regulatory-sequences-is-largely-insufficient\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Annotation of regulatory sequences is largely insufficient<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,9],"tags":[44,1438,1437,1436],"class_list":["post-1394","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-computer-software","tag-dna","tag-computer_programs","tag-junk_dna","tag-regulatory_regions"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1394"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1394\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}