{"id":1450,"date":"2008-01-25T19:47:46","date_gmt":"2008-01-25T17:47:46","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2008\/01\/25\/a-first-mouse-with-asthma\/"},"modified":"2008-01-26T10:35:40","modified_gmt":"2008-01-26T08:35:40","slug":"a-first-mouse-with-asthma","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/01\/a-first-mouse-with-asthma\/","title":{"rendered":"A first mouse with asthma?"},"content":{"rendered":"<p>One of the main reasons that there is not so much progress in asthma and COPD research is a missing good animal model. Despite <a href=\"https:\/\/www.wjst.de\/blog\/2006\/12\/31\/3-rs\/\">some caveats<\/a> such a model could tremendously push a field. A new editorial in the AJRRCCM now believes there could be such a model:<!--more--> &#8220;<a href=\"http:\/\/ajrccm.atsjournals.org\/cgi\/content\/full\/177\/3\/245?etoc\">At Last! A Realistic Animal Model of Severe Asthma<\/a>&#8220;. A closer look at the main premises<\/p>\n<blockquote><p>I suggest that hyperresponsiveness means an increased response to a given dose of agonist leading to excessive, unrestricted airway narrowing.<\/p><\/blockquote>\n<p>uncovers more questions than answers. If we believe that every physiological reaction is dose-dependent and the possibility of hundreds of substances to close any airway, at least this definition is far ahead from what I would like &#8211; an animal <\/p>\n<blockquote><p>genetically determined, spontaneous, exertion and allergen inducible reversible airway inflammation, of intermittent cycles, usually benign but also lethal outcome\n<\/p><\/blockquote>\n<p>While we are still waiting for such a model, you may do your own asthma research <a href=\"http:\/\/www.newscientist.com\/channel\/health\/dn13228-pocket-air-monitor-seeks-out-the-causes-of-asthma.html?feedId=online-news_rss20\">with this gadget<\/a>.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 03.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>One of the main reasons that there is not so much progress in asthma and COPD research is a missing good animal model. Despite some caveats such a model could tremendously push a field. A new editorial in the AJRRCCM now believes there could be such a model: &nbsp; CC-BY-NC Science Surf , accessed 03.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[1529,1527,614,1530,1528],"class_list":["post-1450","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-airway_inflammation","tag-animal_model","tag-asthma_research","tag-exertion","tag-physiological_reaction"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1450"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1450\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}