{"id":1472,"date":"2008-02-01T19:29:56","date_gmt":"2008-02-01T17:29:56","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2008\/02\/01\/a-secosteroid-transcriptional-activator\/"},"modified":"2016-11-12T17:12:28","modified_gmt":"2016-11-12T16:12:28","slug":"a-secosteroid-transcriptional-activator","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/02\/a-secosteroid-transcriptional-activator\/","title":{"rendered":"A secosteroid transcriptional activator"},"content":{"rendered":"<p>A <a href=\"http:\/\/www3.interscience.wiley.com\/cgi-bin\/abstract\/117885976\/ABSTRACT\">new vitamin D review<\/a> is more serious about the biology and possible outcomes <a href=\"http:\/\/content.nejm.org\/cgi\/content\/short\/357\/3\/266\">than some others<\/a>.<\/p>\n<blockquote><p>\nThe popular press is talking about vitamin D as &#8220;The Sunshine Vitamin&#8221;, promoting it as capable of reducing the risk of cancers and autoimmune disease. Yet vitamin D is actually a secosteroid transcriptional activator, at the heart of the innate immunity.\n<\/p><\/blockquote>\n<p>This looks trivial but it isn\u00c2\u00b4t if you look at the NEJM paper<!--more--> cited above.<\/p>\n<blockquote><p>\nthe unsupplemental metabolic homeostasis is probably in the range 23-60 nmol\/l\n<\/p><\/blockquote>\n<p>which is also close to my <a href=\"https:\/\/www.wjst.de\/blog\/2007\/04\/27\/dont-look-at-serum-values-alone\/\">estimate<\/a>. What I did not know so far are the risks discussed with obesity and arthritis. Here is a video from the author<\/p>\n<p><code><br \/>\n<object width=\"425\" height=\"350\"><param name=\"movie\" value=\"http:\/\/www.youtube.com\/v\/RpocxjKJxag\"><\/param><param name=\"wmode\" value=\"transparent\"><\/param><embed src=\"http:\/\/www.youtube.com\/v\/RpocxjKJxag\" type=\"application\/x-shockwave-flash\" wmode=\"transparent\" width=\"425\" height=\"350\"><\/embed><\/object><br \/>\n<\/code><br \/>\ncont&#8217;d<br \/>\n<code><br \/>\n<object width=\"425\" height=\"350\"><param name=\"movie\" value=\"http:\/\/www.youtube.com\/v\/ZMn-zUTTHgw\"><\/param><param name=\"wmode\" value=\"transparent\"><\/param><embed src=\"http:\/\/www.youtube.com\/v\/ZMn-zUTTHgw\" type=\"application\/x-shockwave-flash\" wmode=\"transparent\" width=\"425\" height=\"350\"><\/embed><\/object><br \/>\n<\/code> <\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 10.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A new vitamin D review is more serious about the biology and possible outcomes than some others. The popular press is talking about vitamin D as &#8220;The Sunshine Vitamin&#8221;, promoting it as capable of reducing the risk of cancers and autoimmune disease. Yet vitamin D is actually a secosteroid transcriptional activator, at the heart of &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/02\/a-secosteroid-transcriptional-activator\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">A secosteroid transcriptional activator<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2993,10],"tags":[1589,1588,1586,101,1590,1587,1287],"class_list":["post-1472","post","type-post","status-publish","format-standard","hentry","category-video","category-sunshine-vitamin","tag-cancers","tag-innate-immunity","tag-metabolic-homeostasis","tag-obesity","tag-sunshine","tag-transcriptional-activator","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1472"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1472\/revisions"}],"predecessor-version":[{"id":8555,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1472\/revisions\/8555"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}