{"id":150,"date":"2006-10-06T10:17:00","date_gmt":"2006-10-06T08:17:00","guid":{"rendered":"http:\/\/146.107.134.84\/wordpress\/index.php\/2006\/10\/06\/are-randomized-clinical-trials-really-gold-standard\/"},"modified":"2006-11-11T14:47:00","modified_gmt":"2006-11-11T12:47:00","slug":"are-randomized-clinical-trials-really-gold-standard","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/10\/are-randomized-clinical-trials-really-gold-standard\/","title":{"rendered":"Are randomized clinical trials gold standard?"},"content":{"rendered":"<p>A new paper in the <a href=\"http:\/\/www.aerzteblatt.de\/v4\/archiv\/artikel.asp?src=suche&#038;id=52844\">Deutsche \u00c4rzteblatt<\/a> argues that there should be alternatives to RCTs. The reasons are manifold<\/p>\n<ul>\n<li>selection bias towards more severely ill patients<\/li>\n<li>selection towards too homogeneous samples<\/li>\n<li>patients may decline participation<\/li>\n<li>physician may decline participation<\/li>\n<li>bias towards larger cities and universities<\/li>\n<li>usually &#8220;hard&#8221; endpoints that ignore quality of life, compliance, side effects<\/li>\n<li><span class=\"normal\">usually only short time studies<\/span><\/li>\n<li><span class=\"normal\">protocol may deviate from daily practice in medical routine<\/span><\/li>\n<\/ul>\n<p>Community-based studies may therefore not be as bad, yea, yea.<\/p>\n<h3>Addendum<\/h3>\n<p>An extended and reworked version of this blog can be found in issue 45 of the &#8220;<a href=\"http:\/\/www.aerzteblatt.de\/v4\/archiv\/artikel.asp?src=suche&#038;id=53369\">Deutsche \u00c4rzteblatt<\/a>&#8220;, page A3019, 10th November 2006.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 28.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A new paper in the Deutsche \u00c4rzteblatt argues that there should be alternatives to RCTs. The reasons are manifold selection bias towards more severely ill patients selection towards too homogeneous samples patients may decline participation physician may decline participation bias towards larger cities and universities usually &#8220;hard&#8221; endpoints that ignore quality of life, compliance, side &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/10\/are-randomized-clinical-trials-really-gold-standard\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Are randomized clinical trials gold standard?<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[4,2946],"class_list":["post-150","post","type-post","status-publish","format-standard","hentry","category-philosophy-of-science","tag-population-epidemiology","tag-philosophy-of-science"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/150\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}