{"id":1509,"date":"2008-03-26T19:37:38","date_gmt":"2008-03-26T17:37:38","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2008\/03\/26\/calcium-gradient-in-skin-vitamin-d-and-filaggrin\/"},"modified":"2008-03-26T22:20:13","modified_gmt":"2008-03-26T20:20:13","slug":"calcium-gradient-in-skin-vitamin-d-and-filaggrin","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/03\/calcium-gradient-in-skin-vitamin-d-and-filaggrin\/","title":{"rendered":"Calcium gradient in skin, vitamin D and filaggrin"},"content":{"rendered":"<p>As filaggrin &#8211; one of our best atopy genes &#8211; is <a href=\"http:\/\/www.springerlink.com\/content\/v33v7830520u2833\/\">vitamin D dependent<\/a>, I tried to find out more about epidermal differentiation. The plot here <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15225800?ordinalpos=6&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\">summarizes an earlier review<\/a>:<br \/>\n<a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2008\/03\/cagradient.png\" title='' data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\"><img src='https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2008\/03\/cagradient.png' alt='cagradient.png' \/><\/a><br \/>\nThere seems to be a clear calcium gradient with the <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12445203?ordinalpos=2&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\">expression of differentiation specific marker<\/a> in the single strata. So there is some good chance that filaggrin effects may be modified by external vitamin D supply.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 07.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>As filaggrin &#8211; one of our best atopy genes &#8211; is vitamin D dependent, I tried to find out more about epidermal differentiation. The plot here summarizes an earlier review: There seems to be a clear calcium gradient with the expression of differentiation specific marker in the single strata. So there is some good chance &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/03\/calcium-gradient-in-skin-vitamin-d-and-filaggrin\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Calcium gradient in skin, vitamin D and filaggrin<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[1742,1741,1743,1744,1287],"class_list":["post-1509","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-atopy","tag-candidate-genes","tag-differentiation","tag-filaggrin","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1509"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1509\/revisions"}],"predecessor-version":[{"id":6406,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1509\/revisions\/6406"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}