{"id":1518,"date":"2008-04-12T21:01:36","date_gmt":"2008-04-12T19:01:36","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=1518"},"modified":"2009-05-20T21:43:52","modified_gmt":"2009-05-20T19:43:52","slug":"where-is-the-asthma-gene","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/04\/where-is-the-asthma-gene\/","title":{"rendered":"Where is the asthma gene?"},"content":{"rendered":"<p><a href=\"http:\/\/ajrcmb.atsjournals.org\/cgi\/content\/full\/38\/3\/324\">A new paper<\/a> &#8211; the second bioinfomatics approach following the groundbreaking work by <a href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?tool=pubmed&#038;pubmedid=16115313\">Perez-Iratxeta<\/a> &#8211;  is now coming up with some interesting remarks beyond IL-13 and TGF-\u00df1<!--more-->.<\/p>\n<blockquote><p>\nAn interesting member of the global induction cluster [derived from mouse expression arrays] is module 494 &#8230; This module, regulated by CCL2, Il1RN, and ADAM8, contains 14  genes that exhibit the most persistent activation after treatment of all modules\n<\/p><\/blockquote>\n<p>From the hundreds of association studies, they choose only a few papers including our results on IL1RN (see <a href=\"http:\/\/ajrccm.atsjournals.org\/cgi\/content\/full\/169\/11\/1217\">Gohlke<\/a> \/ <a href=\"http:\/\/www.blackwell-synergy.com\/doi\/abs\/10.1111\/j.1398-9995.2006.00988.x\">Pattaro<\/a>). Maybe these IL1RN antagonists like <a href=\"http:\/\/origin.www.nature.com\/nrd\/journal\/v7\/n4\/full\/nrd2566.html\">Kineret<\/a> are useful in asthma therapy? While this idea may be still premature, here is the link to the <a href=\"http:\/\/www.jail.cs.huji.ac.il\/~shefi\/\">new asthma maps<\/a> &#8211; Where is the asthma gene?<br \/>\n<img src='http:\/\/wjst.de\/blog\/wp-content\/uploads\/2008\/04\/asthmamap.png' alt='' class='alignleft' \/><br \/>\nUnfortunately this doesn&#8217;t map with the recent asthma GWAs by (1) Schauberger (2) Moffat (3) Hui and (4) Choudry. Maybe the 2 forthcoming GWAs will clarify that?<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A new paper &#8211; the second bioinfomatics approach following the groundbreaking work by Perez-Iratxeta &#8211; is now coming up with some interesting remarks beyond IL-13 and TGF-\u00df1 &nbsp; CC-BY-NC Science Surf , accessed 06.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,9],"tags":[1772,199,83,1773,394,1402],"class_list":["post-1518","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-computer-software","tag-il1rn","tag-allergy","tag-asthma","tag-kineret","tag-mouse-model","tag-transgenic_mouse"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1518"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1518\/revisions"}],"predecessor-version":[{"id":2373,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1518\/revisions\/2373"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}