{"id":15343,"date":"2020-02-10T06:00:44","date_gmt":"2020-02-10T06:00:44","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=15343"},"modified":"2022-12-02T09:09:27","modified_gmt":"2022-12-02T07:09:27","slug":"how-it-is-going-how-it-started-asthma-genome-wide-scans","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2020\/02\/how-it-is-going-how-it-started-asthma-genome-wide-scans\/","title":{"rendered":"How it is going, how it started – asthma genome wide scans"},"content":{"rendered":"

Here are the most recent GWAS data for asthma. Peaks are not identical peaks but quite similar.<\/p>\n

How it is going in 2021 …<\/p>\n

PMC5901974<\/a><\/p>\n

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big.stats.ox.ac.uk<\/a><\/p>\n

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pheweb.sph.umich.edu<\/a>\"\"<\/a><\/p>\n

r2.finngen.fi<\/a><\/p>\n

\"\"<\/a><\/p>\n

www.ebi.ac.uk<\/a><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

And here is how it started 1986<\/p>\n

third linkage scan (my PhD thesis)<\/a>
\n\"\"<\/a><\/p>\n

second\u00a0 linkage scan (CSGA)<\/a>
\n\"\"<\/a><\/p>\n

first linkage scan (Cookson)<\/a>
\n\"\"<\/a><\/p>\n

 <\/p>\n

So, more than 2 decades ago we found hits on chromosome 2, 6, 9, 12 (missing\u00a0 chr17q21 where our marker coverage wasn’t probably good enough). It seems that this was the first identification of the IL33 region although IL33 was described only 7 years later<\/a>. Remarkably,\u00a0 this result was possible with just 415\u00a0 individuals instead of 500,000 individuals nowadays (see also the asthma genetics timeline<\/a>).<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 15.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Here are the most recent GWAS data for asthma. Peaks are not identical peaks but quite similar. How it is going in 2021 … PMC5901974 big.stats.ox.ac.uk pheweb.sph.umich.edu r2.finngen.fi www.ebi.ac.uk   And here is how it started 1986 third linkage scan (my PhD thesis) second\u00a0 linkage scan (CSGA) first linkage scan (Cookson)   So, more than … Continue reading How it is going, how it started – asthma genome wide scans<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[3742],"class_list":["post-15343","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-key-biscayne"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/15343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=15343"}],"version-history":[{"count":34,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/15343\/revisions"}],"predecessor-version":[{"id":21189,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/15343\/revisions\/21189"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=15343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=15343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=15343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}