{"id":1699,"date":"2008-09-11T12:11:18","date_gmt":"2008-09-11T10:11:18","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=1699"},"modified":"2008-09-14T11:43:15","modified_gmt":"2008-09-14T09:43:15","slug":"ormdl3-more-inconsistencies-in-the-nature-paper","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/09\/ormdl3-more-inconsistencies-in-the-nature-paper\/","title":{"rendered":"ORMDL3 – more inconsistencies in the Nature paper"},"content":{"rendered":"

It seems that CEA just published my rather critical view of the recent ORMDL3 association<\/a> paper. My letter had been first submitted to “Nature” but rejected after review.
\nA rebuttal seemed to be necessary as the authors repeatedly highlight ORMDL3 as a new asthma gene – in the printed Nature paper, in the Nature podcast and in the accompanying press releases. They even continue with reviews<\/a> saying that<\/p>\n

\nCompletion of the human genome sequence and the advent of genome-wide association studies have resulted in the identification of two novel asthma susceptibility genes, ORMDL3 and CHI3L1, in the past year.\n<\/p><\/blockquote>\n


\nBesides all the facts mentioned in my CEA letter, there even more inconsistencies like unreported population stratification<\/a> and unreported relationship in the German case-control study. I even believe that their figure 3 could not have been produced by the available data. During our recent correspondence the authors insisted that<\/p>\n

\nour figure 3 contained all the information in Dr Wijst’s figure, with the exception that our LD map was drawn from the subjects and markers in our study and not a limited number of individuals in a public database.\n<\/p><\/blockquote>\n

So lets have a look at a (partially cropped and) zoomed version of their original figure 3a<\/a>.
\n\"\"<\/a>
\nWhen plotting their data in the online deposit it turns out that the authors did not have such a high SNP coverage to produce such a high resolution figure.
\n\"\"<\/a>
\nThe redrawn map is clearly different from the printed version while the reason for this inconsistency is unclear. At least the Nature editor wrote<\/p>\n

\npublication of this debate is not justified: this is because in our view it would not add sufficiently to our understanding or otherwise clarify the issues for our readers.\n<\/p><\/blockquote>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 08.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

It seems that CEA just published my rather critical view of the recent ORMDL3 association paper. My letter had been first submitted to “Nature” but rejected after review. A rebuttal seemed to be necessary as the authors repeatedly highlight ORMDL3 as a new asthma gene – in the printed Nature paper, in the Nature podcast … Continue reading ORMDL3 – more inconsistencies in the Nature paper<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[83,727],"class_list":["post-1699","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-asthma","tag-gene"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1699"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1699\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}