{"id":17312,"date":"2020-10-23T18:23:18","date_gmt":"2020-10-23T18:23:18","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=17312"},"modified":"2020-10-23T18:24:13","modified_gmt":"2020-10-23T18:24:13","slug":"ccl4-mip1-b","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2020\/10\/ccl4-mip1-b\/","title":{"rendered":"Covid-19 genetics – Any role of MIP1B?"},"content":{"rendered":"

The first GWAS of severe COVID-19 infection was published in the NEJM<\/a> with the main hit at rs11385942 at locus 3p21.31, a region linked by the authors to LZTFL1. The GWAS catalogue points to MIP1B ( Macrophage Inflammatory Protein 1 beta, MIP-1b, CCL4) level that has been mapped there as well.<\/p>\n

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https:\/\/www.ebi.ac.uk\/gwas\/genes\/LZTFL1<\/figcaption><\/figure>\n
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https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5223028\/<\/figcaption><\/figure>\n

MIP-1B seems to be increased in patients with COVID-19<\/a> as a study showed that levels of various CCGFs<\/a>, including PDGF-BB, CCL5\/RANTES, CCL4\/MIP-1\u03b2, IL-9, and TNF-\u03b2 were upregulated in COVID-19 patients but negatively correlated to disease severity.<\/p>\n

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Supplement https:\/\/www.nature.com\/articles\/s41392-020-0211-1<\/figcaption><\/figure>\n

Another study measured also MIP-1B<\/a> but no major effect<\/p>\n

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Supplement https:\/\/insight.jci.org\/articles\/view\/139834\/sd\/1<\/figcaption><\/figure>\n

A recent Frontiers review<\/a> discusses the relationship to the cytokine storm in fatal COVID-19 infection but again no isolated effect. Nevertheless I have a gut feeling from a 1995 Science paper<\/a> that it could be relevant as it was identified as the major HIV-SF produced by CD8+ T cells (which are so important also in COVID-19 recovery<\/a>).<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 13.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

The first GWAS of severe COVID-19 infection was published in the NEJM with the main hit at rs11385942 at locus 3p21.31, a region linked by the authors to LZTFL1. The GWAS catalogue points to MIP1B ( Macrophage Inflammatory Protein 1 beta, MIP-1b, CCL4) level that has been mapped there as well. MIP-1B seems to be … Continue reading Covid-19 genetics – Any role of MIP1B?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[3547,3391,3390,2585],"class_list":["post-17312","post","type-post","status-publish","format-standard","hentry","category-note-worthy","tag-3p21","tag-covid-19","tag-corona","tag-gwas"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/17312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=17312"}],"version-history":[{"count":6,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/17312\/revisions"}],"predecessor-version":[{"id":17389,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/17312\/revisions\/17389"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=17312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=17312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=17312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}