{"id":1735,"date":"2008-10-21T17:13:13","date_gmt":"2008-10-21T15:13:13","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=1735"},"modified":"2008-10-21T19:18:36","modified_gmt":"2008-10-21T17:18:36","slug":"asthma-a-iatrogenic-disease-contd","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2008\/10\/asthma-a-iatrogenic-disease-contd\/","title":{"rendered":"Asthma: a iatrogenic disease cont’d"},"content":{"rendered":"

I had already a thread here about asthma and iatrogenic factors last month<\/a> including estrogens, vaccines, antibiotics, vitamin D, paracetamol, and Caesarean section. There may be even another kid on the block: folate. At least in mice in utero supplementation with methyl donors enhances allergic airway disease<\/a><\/p>\n

\nUsing a genomic approach, we discovered 82 gene-associated loci that were differentially methylated after in utero supplementation with a methyl-rich diet. These methylation changes were associated with decreased transcriptional activity and increased disease severity. Runt-related transcription factor 3 (Runx3), a gene known to negatively regulate allergic airway disease, was found to be excessively methylated, and Runx3 mRNA and protein levels were suppressed in progeny exposed in utero to a high-methylation diet.\n<\/p><\/blockquote>\n

I didn’t know that there are already 57 Pubmed records on that – but recall a recent Clin Exp All<\/a> paper on the association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a ALSPAC birth cohort. They find, however,<\/p>\n

\nThe results of this study do not support the hypothesis that impaired folate metabolism is associated with allergy in adults or children in this population.\n<\/p><\/blockquote>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 09.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

I had already a thread here about asthma and iatrogenic factors last month including estrogens, vaccines, antibiotics, vitamin D, paracetamol, and Caesarean section. There may be even another kid on the block: folate. At least in mice in utero supplementation with methyl donors enhances allergic airway disease   CC-BY-NC Science Surf , accessed 09.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[2233,2241,2230,2235,2236,80,2229,2234,284,2237,102,53,2238,2232,1087,2231,2240,481,2239,1287],"class_list":["post-1735","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-airway-disease","tag-antibiotics","tag-disease-severity","tag-factor-3","tag-kid-on-the-block","tag-loci","tag-methyl-donors","tag-methylated","tag-methylation","tag-mrna","tag-ncbi","tag-nih","tag-progeny","tag-protein-levels","tag-pubmed","tag-rich-diet","tag-supplementation","tag-transcription-factor","tag-vaccines","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1735"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1735\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}