{"id":19026,"date":"2022-01-16T14:45:56","date_gmt":"2022-01-16T12:45:56","guid":{"rendered":"https:\/\/www.wjst.de\/blog\/?p=19026"},"modified":"2023-09-05T03:24:14","modified_gmt":"2023-09-05T01:24:14","slug":"rare-variants-in-gsdma-b-ikzf3-but-not-in-ormdl3-are-relevant-for-asthma","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2022\/01\/rare-variants-in-gsdma-b-ikzf3-but-not-in-ormdl3-are-relevant-for-asthma\/","title":{"rendered":"Rare variants in GSDMA\/B \/IKZF3 but not in ORMDL3 are relevant for asthma"},"content":{"rendered":"

It was a heated debate (paper<\/a>, blog<\/a>) that was open<\/a> until a most recent study<\/a> that I am depicting here in more detail.<\/p>\n

\"\"<\/a>
IKZF3<\/figcaption><\/figure>\n
\"\"<\/a>
ORMDL3<\/figcaption><\/figure>\n
\"\"<\/a>
GSDMB<\/figcaption><\/figure>\n

Maybe there is an interaction<\/a> by methylation?<\/p>\n

The\u00a0 analysis of\u00a0 SNP effects is ongoing while it now looks like ORMDL3 SNPs were just hitchhikers, at least what I see<\/a>.<\/p>\n

 <\/p>\n

Addendum 4.9.2023<\/span><\/p>\n

Maybe there is even a vitamin interaction<\/a>?<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 24.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

It was a heated debate (paper, blog) that was open until a most recent study that I am depicting here in more detail. Maybe there is an interaction by methylation? The\u00a0 analysis of\u00a0 SNP effects is ongoing while it now looks like ORMDL3 SNPs were just hitchhikers, at least what I see.   Addendum 4.9.2023 … Continue reading Rare variants in GSDMA\/B \/IKZF3 but not in ORMDL3 are relevant for asthma<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[3701,4222,3702,83],"class_list":["post-19026","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-cookson","tag-ikzf3","tag-moffatt","tag-asthma"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/19026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=19026"}],"version-history":[{"count":10,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/19026\/revisions"}],"predecessor-version":[{"id":22622,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/19026\/revisions\/22622"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=19026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=19026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=19026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}