{"id":1924,"date":"2009-01-16T14:36:05","date_gmt":"2009-01-16T12:36:05","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=1924"},"modified":"2009-01-16T14:38:53","modified_gmt":"2009-01-16T12:38:53","slug":"tcr-hla-b4405eenlldfvrf","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/01\/tcr-hla-b4405eenlldfvrf\/","title":{"rendered":"TCR-HLA-B*4405(EENLLDFVRF)"},"content":{"rendered":"<p>There are <a href=\"http:\/\/www.plosone.org\/article\/info:doi%2F10.1371%2Fjournal.pone.0000876\">not two cells in the human body<\/a> that have an identical DNA sequence as <a href=\"https:\/\/www.wjst.de\/blog\/2007\/01\/12\/a-longe-fuse\/\">detailed here earlier<\/a>.  But not only ageing, already basic B and T cell recombination introduces variation. And there might be more: HLA micropolymorphism!<!--more--> A <a href=\"http:\/\/jem.rupress.org\/cgi\/content\/full\/jem.20082136v1\">new JEM paper<\/a> describes<\/p>\n<blockquote><p>\nMaintenance of HLA polymorphism reflects natural selection for enhanced protective immunity against the pathogens encountered by humans. The MHC molecules can differ from each other by either >30 amino acids or only a few amino acids (micropolymorphism). This MHC-I polymorphism is generally concentrated in the antigen-binding cleft, controlling the size and diversity of the peptide repertoire presented by each HLA molecule.\n<\/p><\/blockquote>\n<p>Fortunately TCR degeneracy allows even non EENLLDFVRF cells to recognize EBV, yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 15.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>There are not two cells in the human body that have an identical DNA sequence as detailed here earlier. But not only ageing, already basic B and T cell recombination introduces variation. And there might be more: HLA micropolymorphism! &nbsp; CC-BY-NC Science Surf , accessed 15.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-1924","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=1924"}],"version-history":[{"count":5,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1924\/revisions"}],"predecessor-version":[{"id":1929,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/1924\/revisions\/1929"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=1924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=1924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=1924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}