{"id":2121,"date":"2009-04-22T11:37:40","date_gmt":"2009-04-22T09:37:40","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=2121"},"modified":"2009-04-22T11:37:40","modified_gmt":"2009-04-22T09:37:40","slug":"shift-happens","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/04\/shift-happens\/","title":{"rendered":"Shift happens"},"content":{"rendered":"<p>The <a href=\"http:\/\/ajrccm.atsjournals.org\/cgi\/content\/full\/179\/9\/739\">current issue of the blue journal<\/a> has more stuff on the <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10442534?ordinalpos=2&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\">vitamin D hypothesis<\/a> (that has been <a href=\"http:\/\/www.sciencedirect.com\/science?_ob=ArticleURL&#038;_udi=B6WH4-4R00FB0-7&#038;_user=100078&#038;_rdoc=1&#038;_fmt=&#038;_orig=search&#038;_sort=d&#038;view=c&#038;_acct=C000007458&#038;_version=1&#038;_urlVersion=0&#038;_userid=100078&#038;md5=d238cc20f9bfce8d4d01938e6e7bac13\">shifted recently<\/a> into the opposite direction). I agree with the editorial that<\/p>\n<blockquote><p>\nIntervention studies of vitamin D in the primary prevention and treatment of asthma raise a number of difficult scientific, ethical, and regulatory issues.\n<\/p><\/blockquote>\n<p>That may be true while the editorial includes the widely quoted myth that immunological effects occur only at high doses<!--more--> (at least it provides no good reference). And sure, I am misquoted with effects on Th2 (never said that) as well as on asthma (so far I talked only about sensitization).<\/p>\n<blockquote><p>\nWithout dietary supplementation, humans obtain about 90% of their vitamin D from sunlight exposure and 10% from diet\n<\/p><\/blockquote>\n<p>is also not correct as a newborn will get 99,5% from sunlight. On the other hand I liked the note that<\/p>\n<blockquote><p>\nhumans cannot overdose on vitamin D from sunshine because excessive pre\u00e2\u20ac\u201cvitamin D is destroyed by sunlight to inactive photoproducts, and repeated exposures stimulate tanning. This does not happen with dietary vitamin D, where there is clear potential for overdosing.\n<\/p><\/blockquote>\n<p>For those who have not attended the recent session of the AAAAI in Washington, here is a possible and rather simple explanantion of the Weiss et al. findings. Supplements may be  more effective in hypovitaminic individuals, yea, yea.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2009\/04\/screenshot2.png\" alt=\"screenshot2\" title=\"screenshot2\" width=\"450\" height=\"293\" class=\"alignnone size-full wp-image-2150\" \/><\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>The current issue of the blue journal has more stuff on the vitamin D hypothesis (that has been shifted recently into the opposite direction). I agree with the editorial that Intervention studies of vitamin D in the primary prevention and treatment of asthma raise a number of difficult scientific, ethical, and regulatory issues. That may &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/04\/shift-happens\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Shift happens<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,5,10],"tags":[199,1891,1287],"class_list":["post-2121","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-philosophy-of-science","category-sunshine-vitamin","tag-allergy","tag-controversy","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=2121"}],"version-history":[{"count":15,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2121\/revisions"}],"predecessor-version":[{"id":2164,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2121\/revisions\/2164"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=2121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=2121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=2121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}