{"id":22671,"date":"2023-10-07T07:44:37","date_gmt":"2023-10-07T05:44:37","guid":{"rendered":"https:\/\/www.wjst.de\/blog\/?p=22671"},"modified":"2023-10-07T07:47:26","modified_gmt":"2023-10-07T05:47:26","slug":"sun-wind-allergy","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2023\/10\/sun-wind-allergy\/","title":{"rendered":"sun + wind + allergy"},"content":{"rendered":"

New work by Harvard colleagues shows how sunshine hormone\u00a0 D constrains inflammation<\/a> by modulating the expression of key genes on chr17q<\/a>. It builds on earlier collaborative work on the vitamin D receptor in 2004 (see their ref 5<\/a>) as well on my annotation of IKZF3 (aka aiolos aka god of winds)<\/a> in 2008 \u00a0and again<\/a>\u00a0in 2022.<\/p>\n

While our focus on allergy development was on vitamin D supplementation of newborns, the interest of Weiss et al. was on vitamin D deficiency in pregnancy.\u00a0 Vitamin D deficiency may not be attributed to the rise of the asthma and allergy epidemic <\/a>although this remains the never ending obsession of Weiss et al.<\/p>\n

Nevertheless, also a wrong hypothesis may lead to new insights.\u00a0 IKZF3 clearly is a key player<\/a> where more recently heterozygous missense\/LOF variants have been found in families with B-lymphopenia and EBV-associated lymphoma while the allergy proning effect is more in the 5-prime region<\/a>.<\/p>\n

The new study shows (again) that cholecalciferol suppresses the activation of the IL-2 pathway. But what is the net effect of artifical cholecalciferol exposure on naive T cells? Unfortunately the\u00a0 new paper narrowly focuses on cytokine production in Th2 cells only and even misses the famous Cantorna review<\/a> that clearly says<\/p>\n

\u00a0Since 1983 it has been described that 1,25(OH)2<\/sub>D inhibited T cell proliferation and the secretion of select cytokines after mitogen stimulation. Moreover, 1,25(OH)2<\/sub>D directly inhibited IL-2 and IFN-\u03b3 transcription [17<\/a>,18<\/a>]. More recently 1,25(OH)2<\/sub>D has also been shown to inhibit IL-17 secretion by Th17 cells. The effects of 1,25(OH)2<\/sub>D on Th2 cells is more controversial with evidence that 1,25(OH)2<\/sub>D inhibits IL-4 transcriptionally as well as evidence that 1,25(OH)2<\/sub>D upregulates IL-4 in mouse and human T cells.<\/p><\/blockquote>\n

So\u00a0 we need to rephrase the finding of an “immune protective effect of vitamin D in allergic lung inflammation” to an overall “immune suppressive effect of vitamin D” which is basic textbook knowledge. Unfortunately the early origin of allergy induction remains a mystery.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 29.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

New work by Harvard colleagues shows how sunshine hormone\u00a0 D constrains inflammation by modulating the expression of key genes on chr17q. It builds on earlier collaborative work on the vitamin D receptor in 2004 (see their ref 5) as well on my annotation of IKZF3 (aka aiolos aka god of winds) in 2008 \u00a0and again\u00a0in … Continue reading sun + wind + allergy<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2,10],"tags":[],"class_list":["post-22671","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/22671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=22671"}],"version-history":[{"count":7,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/22671\/revisions"}],"predecessor-version":[{"id":22753,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/22671\/revisions\/22753"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=22671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=22671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=22671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}