{"id":2395,"date":"2009-05-22T21:04:15","date_gmt":"2009-05-22T19:04:15","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=2395"},"modified":"2016-11-12T17:12:27","modified_gmt":"2016-11-12T16:12:27","slug":"forget-about-genes-i","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/05\/forget-about-genes-i\/","title":{"rendered":"Forget about genes I"},"content":{"rendered":"<p>An <a href=\"http:\/\/www.sciencedirect.com\/science?_ob=ArticleURL&#038;_udi=B8JDD-4VJ5CN5-5&#038;_user=10&#038;_rdoc=1&#038;_fmt=&#038;_orig=search&#038;_sort=d&#038;view=c&#038;_acct=C000050221&#038;_version=1&#038;_urlVersion=0&#038;_userid=10&#038;md5=e09a659a9cacbe58efe76a34595180cf\">AJHG<\/a> paper that is already resting some longer time on my desk says that<\/p>\n<blockquote><p>\nNonsense SNPs introduce premature termination codons into genes and can result in the absence of a gene product &#8230;<!--more--> As such, we might expect the disrupted allele to be rare and, in healthy people, observed only in a heterozygous state  &#8230; we have carried out a large-scale experimental survey of nonsense SNPs in the human genome by genotyping 805 of them &#8230; in 1,151 individuals &#8230; We identified 169 genes containing nonsense SNPs that were variable in our samples, of which 99 were found with both copies inactivated in at least one individual.\n<\/p><\/blockquote>\n<p>It seems that it doesn&#8217; t even matter if you have lost some genes as there is an enormous plasticity of the human genome where obviously other genes can easily take over, where we have <a href=\"http:\/\/www.youtube.com\/watch?v=oHg5SJYRHA0\">many more examples<\/a>, yea, yea. <\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 09.06.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>An AJHG paper that is already resting some longer time on my desk says that Nonsense SNPs introduce premature termination codons into genes and can result in the absence of a gene product &#8230; &nbsp; CC-BY-NC Science Surf , accessed 09.06.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,2993],"tags":[1972,2474],"class_list":["post-2395","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-video","tag-human-genetics","tag-lost-gene-function"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=2395"}],"version-history":[{"count":6,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2395\/revisions"}],"predecessor-version":[{"id":8544,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2395\/revisions\/8544"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=2395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=2395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=2395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}