{"id":24376,"date":"2024-12-09T15:18:46","date_gmt":"2024-12-09T13:18:46","guid":{"rendered":"https:\/\/www.wjst.de\/blog\/?p=24376"},"modified":"2025-01-12T09:41:30","modified_gmt":"2025-01-12T07:41:30","slug":"update-on-mendelian-randomization","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2024\/12\/update-on-mendelian-randomization\/","title":{"rendered":"Update on Mendelian Randomization"},"content":{"rendered":"<p><a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2016\/11\/low-serum-vitamin-d-reverse-causation-or-true-risk-factor\/\">As written before<\/a>\u00a0I never published any study that included a Mendelian randomization. The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Mendelian_randomization\">reasons are well known.<\/a><\/p>\n<p>A <a href=\"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-024-02284-w\">new paper from Bristol<\/a> discusses \u00a0the \u00a0recent explosion of low-quality two-sample Mendelian randomization studies and offers a cure.<\/p>\n<blockquote>\n<p class=\"p1\">We advise editors to simply reject papers that only report 2SMR findings, with no additional supporting evidence. For reviewers receiving such papers, we provide a template for rejection.<\/p>\n<\/blockquote>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 28.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>As written before\u00a0I never published any study that included a Mendelian randomization. The reasons are well known. A new paper from Bristol discusses \u00a0the \u00a0recent explosion of low-quality two-sample Mendelian randomization studies and offers a cure. We advise editors to simply reject papers that only report 2SMR findings, with no additional supporting evidence. For reviewers &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2024\/12\/update-on-mendelian-randomization\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Update on Mendelian Randomization<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,9],"tags":[4953,4954,1287],"class_list":["post-24376","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-computer-software","tag-mendelian","tag-randomization","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/24376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=24376"}],"version-history":[{"count":9,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/24376\/revisions"}],"predecessor-version":[{"id":24496,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/24376\/revisions\/24496"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=24376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=24376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=24376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}