A new review [Allergy (2009) vol. 64 (3) pp. 348-353] examines the evidence that<\/p>\n
\n(1) failure to up-regulate the interferon gamma (IFNg) response during infancy is an important determinant of the risk of allergic disease
\n(2) expression of the IFNg gene in naive T-cells is regulated by epigenetic mechanisms, and
\n(3) failure to up-regulate IFNg gene expression of naive T-cells associated with low early life microbial exposure.\n<\/p><\/blockquote>\nIf we replace “microbial exposure” with “vitamin D supplementation” this sounds like a reasonable model according to more<\/a> papers<\/a> that argue<\/a><\/p>\n
\nstudies combining early life epidemiological data with an investigation of the kinetics of IFNg demethylation in naive T-cells, whilst logistically scienti\u00ef\u00ac\u0081cally challenging, are a promising line of future inquiry.\n<\/p><\/blockquote>\n
yea, yea.<\/p>\n\n
<\/p>\n
\n CC-BY-NC Science Surf , accessed 15.06.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"A new review [Allergy (2009) vol. 64 (3) pp. 348-353] examines the evidence that (1) failure to up-regulate the interferon gamma (IFNg) response during infancy is an important determinant of the risk of allergic disease (2) expression of the IFNg gene in naive T-cells is regulated by epigenetic mechanisms, and (3) failure to up-regulate IFNg … Continue reading 1, 2, 3<\/span>