{"id":2569,"date":"2009-06-20T20:57:03","date_gmt":"2009-06-20T18:57:03","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=2569"},"modified":"2009-06-20T20:57:03","modified_gmt":"2009-06-20T18:57:03","slug":"forget-about-genes-v","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/06\/forget-about-genes-v\/","title":{"rendered":"Forget about genes V"},"content":{"rendered":"<p><a href=\"http:\/\/www.genomeweb.com\/sequencing\/life-after-gwas-some-researchers-focus-shifts-rare-variants-cnvs?emc=el&#038;m=421535&#038;l=8&#038;v=f4505f4c37\">Life after GWAS<\/a> comments<\/p>\n<blockquote><p>\nAllen Roses, director of the Deane Drug Discovery Institute at Duke University, noted that GWAS has &#8220;largely disappointed its most enthusiastic proponents<!--more-->&#8221; because it has not been able to identify genes responsible for complex diseases. This disappointment, he said, is because &#8220;GWAS was never meant to substitute for fine genomic sequencing,&#8221; but rather to identify regions of linkage disequilibrium in the genome that warrant further study.\n<\/p><\/blockquote>\n<p>After the low linkage scores, the weak GWA effect sizes, we need for whole-genome sequencing before accepting my title&#8230;<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 05.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Life after GWAS comments Allen Roses, director of the Deane Drug Discovery Institute at Duke University, noted that GWAS has &#8220;largely disappointed its most enthusiastic proponents &nbsp; CC-BY-NC Science Surf , accessed 05.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[2517,1114,961],"class_list":["post-2569","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-complex","tag-gwa","tag-sequencing"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=2569"}],"version-history":[{"count":2,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2569\/revisions"}],"predecessor-version":[{"id":2571,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/2569\/revisions\/2571"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=2569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=2569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=2569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}