Tacrolimus and vitamin D both suppress IL-2 production.<\/p>\n
The mechanisms of IL-2 suppression is different<\/a> however. Tacrolimus binds FKBP12 to inhibit calcineurin, blocking NFAT dephosphorylation and IL-2 gene transcription in activated T cells. Vitamin D (1,25(OH)\u2082D\u2083) activates VDR to directly inhibit IL-2 promoter. High vitamin D levels correlate with reduced IL-2\u00a0 and Th1 suppression.<\/p>\n Oral vitamin D are pro-allergic in newborns as I have described in a dozen papers.<\/a> So if the prohormone vitamin D and\u00a0 the calcineurin inhibitor tacrolimus share the same immunological endpoint IL2, I would anticipate that tacrolimus can make you allergic. And well\u00a0 – only today I discovered that is is true while working on an unrelated review of tacrolimus. So let\u2018s search the literature https:\/\/doi.org\/10.1111\/j.1365-2222.2011.03761.x<\/a> says<\/p>\n Results The prevalence of sensitization was significantly higher in the tacrolimus- than in the cyclosporin A-treated group (34%, n = 34, vs. 20%, n = 20; P = 0.026). The rate of clinically relevant allergy in patients receiving tacrolimus was twice that in patients receiving\u00a0 cyclosporin A (15%, n = 15, vs. 8%, n = 8; P = 0.12).<\/p>\n<\/blockquote>\n So this study\u00a0 seems to confirm my hypothesis. Let’s look at another study https:\/\/doi.org\/10.1016\/j.aller.2017.09.030<\/a><\/p>\n Transplant acquired food allery was found in 7\/12 (58%) children with liver transplantations and in none of the 10 children with kidney transplantations.<\/p><\/blockquote>\n This study has another interesting observation. Conceptually, the \u201cportal\u2013hepatic immune filter + tacrolimus\u2011induced Th2 shift + high early antigen load in a young gut\u201d model is consistent with this paper. The kidney, lacking this gut\u2013portal interface and typically being transplanted in older children, sits in a different immunologic context, which likely explains why tacrolimus appears \u201callergy\u2011inducing\u201d only in the liver setting rather than via renal blood flow .<\/p>\n\n <\/p>\n Tacrolimus and vitamin D both suppress IL-2 production. The mechanisms of IL-2 suppression is different however. Tacrolimus binds FKBP12 to inhibit calcineurin, blocking NFAT dephosphorylation and IL-2 gene transcription in activated T cells. Vitamin D (1,25(OH)\u2082D\u2083) activates VDR to directly inhibit IL-2 promoter. High vitamin D levels correlate with reduced IL-2\u00a0 and Th1 suppression. Oral … Continue reading Tacrolimus shares the allergy inducing pathway with vitamin D<\/span> \n